Common drugs such as non-steroidal anti-inflammatories are some of the most deadly to cats. Newer modifications of phenol peels with reduced levels of croton oil have significantly reduced the amount of postoperative hypopigmentation, postoperative erythema, and scarring. While previous investigations have concluded that in cats the gene for the phenol-type glucuronosyltransferase isoform has turned into a pseudogene because of several point mutations, evaluation of genomic information for snake species revealed that they have only 2 genes that may code for glucuronosyltransferase isoforms. depends o n it s arom atic ring where benz ene ring itself . Diagnosis of phenol and phenolic poisoning is either on a rule out basis or by witnessing it firsthand. I was wondering if anyone here was thinking about toxic substances present in insulin formulations. Joined Dec 21, 2005 Messages 2,155 Reaction score 2. 2,6-diisopropyl phenol 2,6-bis(1-methylethyl)phenol Supplier Sponsors. Could you direct me to a site. Vet Rec. In the case of cats, poisoning happens by absorption through the skin, although ingestion does happen sometimes. Eating garbage or feeding food which is out of date, improperly stored or improperly handled. Systemic toxicity can result from skin or eye exposures. Primarily, the values are clustered in the range 250–500 mg/kg, although the value Food poisoning is another common cause of poisoning in cats. RELEVANT BACKGROUND INFORMATION 2.1 Explanation. Comments. Cats 1–2 U per cat q 12 hr. Both of these substances are very toxic, and for someone who is injecting 20 units of insulin per day, means also 300 ppm of phenol per day and 344 ppm of m-cresol. The oral bioavailability of aspirin may vary because of differences in drug formulation. Oral median lethal doses (LD 50) for phenol are listed in the HSDB [], Lewis [], and Berman et al. Here are Some Essential Oils that are Safe to Diffuse around Cats Some of these essential oils are void of the organic compound phenol and if any is however present, then it must have reduced in terms of its concentration to a level where it is bearable for cats.. Cedarwood Essential Oil. In cats, toxicity can occur with 10–40 mg/kg. ERNST MR, KLESMER R, HUEBNER RA, MARTIN JE. Coal tar: Coal tar is found in products like cresols, creosote, and phenol, and it's included in household disinfectants. Vitamin toxicity can also occur in cats who have been given vitamin supplements or cod liver oil. It is a colorless-to-white solid when pure. Acute toxicity has been observed in man and experimental animals, resulting in muscle weakness, convul sions, and coma. Cats lack an essential enzyme in their liver and as such have difficulty metabolizing and eliminating certain toxins like essential oils. 735) established by the 1999 Joint FAO/WHO Meeting on Pesticide Residues (FAO, 1999). Essential oils toxicity in cats: Everything you need to know. And that is 1984! Acute keratoconjunctivitis sicca has been reported in some dogs after acetaminophen ingestion. 100%), the greater the risk to the cat. This kind of poisoning causes the stimulation of the nervous system, weakening of the heart and liver damage. Summary of Mammalian Toxicity Mammalian Oral Toxicity - Acute. Last updated on June 14, 2020 Home ... Cats lack the enzymes in their bodies that break down certain components of essential oils. Disinfectant toxicity in cats is summarized in table 1. Cases of toxicosis in this species are most often the result of inappropriate administration. MA was telling a member about the toxicity of Pine Sol to cats. Susceptibility of cats to phenol. Although not all of these side effects may occur, if they do occur they may need medical attention. This enzyme protects animals from toxins or harmful substances like those scents from essential oil. Treatment in all patients was supportive and symptomatic, and the most commonly used anticonvulsants were diazepam and barbiturates; however, severe unresponsive seizures in three dogs had to be controlled with inhalant gas anaesthesia. When ingested, NSAIDS can result in severe, acute kidney failure (ARF) and gastrointestinal injury/ulcers. 1976 Oct 16;99(16):319. Weaker solutions of phenol (25% to 50%) can be used to achieve lighter peels; however, the results are not better than TCA and there is still the risk for systemic toxicity. Basically, the higher the concentration of the essential oil (such as one not diffused with carrier oil), the higher the toxicity. Hot oils like cinnamon, nutmeg, and thyme contain the highest levels of phenol and can be the most offensive to cats. While most cases 2/7. It is a white crystalline solid that is volatile. Here we are – some 33 years later, still questioning if essential oils are killing cats, and reporting all over the place that it is a huge area of concern. Glargine (long-acting) Product Description. Methemoglobinemia and hepatotoxicity characterize acetaminophen toxicosis. Phenol vapor and liquid penetrate the skin with an absorption efficiency approximately equal to the absorption efficiency by inhalation. Cats may experience toxicosis at dosages exceeding 50 mg/kg, but severe toxicosis was not seen in an experimental setting until repeated exposures greater than 80 mg/kg were administered. Then, when cats groom, they ingest the cleaner which damages their liver and kidneys. It is commonly used as a room deodorizer and can be used with other oils for an invigorating massage. The Committee took note of the ADI of 0-0.4 mg/kg bw for 2-phenylphenol (No. Because of cats' limited ability to metabolize carprofen via glucuronidation, the drug's elimination half-life (20.1 ± 16.6 hours)21 in that species is longer than in dogs. Cats have difficulty metabolizing certain drugs due to their altered liver metabolism, especially as compared to dogs and humans. “Even drugs known for toxicity in cats can be used safely if we are aware of and compensate for certain peculiarities.” That basically says it all. This monograph summarizes data pertinent to … 100%), the greater the risk to the cat. Since it has high phenol content, its use around cats is strongly discouraged because of the risk of toxicity. This organic compound is present in many essential oils, making them unsafe to use around pets especially cats. The higher the concentration of the essential oil (i.e. The cat shows remarkable sensitivity to the adverse effects of phenolic drugs, including acetaminophen and aspirin, as well as structurally-related toxicants found in the diet and environment. The commercial product is a liquid. People have no problem with that. Phenol poisoning in the cat. Phenols . Dodman NH, Bogan J, Thompson H. PMID: 982778 [PubMed - indexed for MEDLINE] Publication Types: Cats are also very sensitive to phenols and phenolic compounds, which can be found in some essential oils. Acute toxicity (96 h LC50) of phenol was analyzed in the cat fish Mystus vittatus in static bio-assay over a 96-h exposure period using probit method. J Am Vet Med Assoc. Consequently, use of the drug in cats poses a far greater risk of adverse effects. Although hypothermia was very common, especially in cats (90.9%), hyperthermia was frequently observed in dogs (21%). The onset, severity and duration of toxicity is determined by the dose, route of exposure, physicochemical properties of the organophosphate (e.g. The higher the concentration of the essential oil (i.e. WILDLIFE TOXICITY ASSESSMENT FOR PHENOL 4 2.3 Summary of Mammalian Toxicity 2.3.1 Mammalian Oral Toxicity 2.3.1.1 Mammalian Oral Toxicity - Acute Oral median lethal doses (LD 50s) for phenol have been given in Lewis (1992), HSDB (2002), and Berman et al. 1961 Feb 15;138:197-9. Applies to phenol topical: oromucosal spray, oromucosal suspension. Commonly used in cats; not commonly used in dogs. Another plant similar to pine trees, the oil from spruces is known for its characteristic clean pine smell. Ingestion of the oil can cause seizures in cats. Recombinant DNA origin human insulin. I can't find an exact quantity of onions required to cause toxicity problems in dogs, but there are several case reports of onion toxicity and they involve whole onions or sizable portions of chopped onions (like a cup or more). Mildly acidic, it requires careful handling because it can cause chemical burns. Other data on the toxicity of phenol and its derivatives were consistent with the results of the safety evaluation. That is important information for all members. Check with your doctor immediately if any of the following side effects occur while taking phenol … The symptoms he may display are not commonly seen in anything other than a type of toxicity. Phenol is an aromatic organic compound with the molecular formula C 6 H 5 OH. I clean with pine sol and never had a problem with my cats in 12 years. Berje Inc. Where the world comes to its senses : Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals. 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